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Methylation法およびTranscription法を用いたOligodendrogliomaにおけるClonality Analysis
http://hdl.handle.net/10470/24726
http://hdl.handle.net/10470/247266c3e9b34-ce91-4655-9c88-5b4ca60c5cd0
名前 / ファイル | ライセンス | アクション |
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KJ00006020759.pdf (1.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | Methylation法およびTranscription法を用いたOligodendrogliomaにおけるClonality Analysis | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Methylation- and Transcription-based Clonality Analysis of Oligodendroglioma | |||||
著者名 |
丸山, 隆志
× 丸山, 隆志 |
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著者別名 | ||||||
姓名 | MARUYAMA, Takashi | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 69, 号 5, p. 251-259, 発行日 1999-05-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Characterization of the clonal derivation of human neoplasms has provided important information about the etiology and pathogenesis, and has oractical implications for both the diagnosis and subsequent studies on disease progression. ln the oresent study, molecular srenetic assays, including methylation- and transcription-based donal techniques were used to determine the clonality of 13 oligodendroglioma oatients (16 samples). Analysis of the tumors with PCR-based methylation assays at the androgen receotor locus (HUMARA)confirmed that three informative benign sarrmles and two of eight malignant sairmles were monoclonal, and the remaining six malignant samples were all polyclonal. Of three patients who had two separate operations, two consistently showed both monoclonal, and one showed monoclonal at the first operation, then changed to polyclonal. Transcription-based analysis showed four informative benign samples and three of six were malignant samples were monoclonal, while the remaining three were polyclonal. Two samples, which showed polyclonal findings by methylation-based analysis, were demonstrated to be monoclonal by transcription-based analysis. Our data demonstrated that many tumors consist of homogeneous clonal cells in origin but some are mixed, showing both heterogeneous cells and other populations of clonal cells. | |||||
著者所属 | ||||||
東京女子医科大学医学部脳神経外科学 |