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ブドウ球菌スーパー抗原TSST-1の長時間暴露によるウサギ毒素性ショック症候群の誘導とその病態の解析
http://hdl.handle.net/10470/24955
http://hdl.handle.net/10470/24955860b389b-719f-4bb5-9715-d1fde1ead3d5
名前 / ファイル | ライセンス | アクション |
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KJ00006020864.pdf (645.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | ブドウ球菌スーパー抗原TSST-1の長時間暴露によるウサギ毒素性ショック症候群の誘導とその病態の解析 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Pathogenic Mechanism of Toxic Shock Syndrome in Rabbits Induced by Long-term Exposure to Staphylococcal Superantigen TSST-1 | |||||
著者名 |
河内, 章
× 河内, 章× 上芝, 秀博× 石川, 和男× 三和, 敬史× 井田, 伸夫× 原, 康× 多川, 政弘× 金井, 孝夫× 内山, 竹彦 |
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著者別名 | ||||||
姓名 | KAWACHI, Akira | |||||
著者別名 | ||||||
姓名 | UESHIBA, Hidehiro | |||||
著者別名 | ||||||
姓名 | ISHIKAWA, Kazuo | |||||
著者別名 | ||||||
姓名 | MIWA, Keishi | |||||
著者別名 | ||||||
姓名 | IDA, Nobuo | |||||
著者別名 | ||||||
姓名 | HARA, Yasushi | |||||
著者別名 | ||||||
姓名 | TAGAWA, Masahiro | |||||
著者別名 | ||||||
姓名 | KANAI, Takao | |||||
著者別名 | ||||||
姓名 | UCHIYAMA, Takehiko | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 69, 号 9/10, p. 571-578, 発行日 1999-10-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A Staphylococcal infectious disease, toxic shock syndrome (TSS), is characterized by acute and systemic disorders, such as fever, erythema, shock, and multi-organ failures. A causative exotoxin of TSS, TSS toxin-1 (TSST-1), one of the bacterial superantigens, activates a vast number of human T cells in Vβ2-selective way and induces overproduction of cytokines. However, it does not exhibit direct cytotoxic actions. Cytokines produced in an excessive amount are primarily involved in the pathogenicity of TSS. In the present study, we analyse abnormal reactions seen in TSS in rabbits induced by long-term exposure to TSST-1 filled in an osmotic pump implanted. All of the rabbits exposed to TSST-1 exhibited acute and systemic abnormal reactions and 60% of them died within 14 days. The rabbits which survived TSS exhibited transient decrease in body weight, erythrocyte counts, and concentration of hemoglobin in peripheral blood, and transient increases in serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, lactate dehydrogenase, triglyceride, and total cholesterol values. By comparison, the rabbits that died exhibited steady decreases in body weight, erythrocyte counts, and concentration of hemoglobin in peripheral blood prior to their deaths, and transient increases, in higher degrees than did survived ones, of the other clinical data described above. | |||||
著者所属 | ||||||
東京女子医科大学医学部微生物学免疫学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部実験動物中央施設 | ||||||
著者所属 | ||||||
東京女子医科大学医学部微生物学免疫学:(株)東レ医療システム研究所 | ||||||
著者所属 | ||||||
(株)東レ医療システム研究所 | ||||||
著者所属 | ||||||
(株)東レ医療システム研究所 | ||||||
著者所属 | ||||||
日本獣医畜産大学獣医外科学 | ||||||
著者所属 | ||||||
日本獣医畜産大学獣医外科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部実験動物中央施設 | ||||||
著者所属 | ||||||
東京女子医科大学医学部微生物学免疫学:東京女子医科大学医学部実験動物中央施設 |