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小児心不全患者におけるシラザプリルの効果
http://hdl.handle.net/10470/26124
http://hdl.handle.net/10470/26124e66a2aeb-e718-4b69-9d4c-465e3a8d1e1d
名前 / ファイル | ライセンス | アクション |
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KJ00006019679.pdf (417.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | 小児心不全患者におけるシラザプリルの効果 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Effect of Cilazapril in Children with Heart Failure | |||||
著者名 |
間, 峡介
× 間, 峡介 |
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著者別名 | ||||||
姓名 | HAZAMA, Kyosuke | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 72, 号 12, p. 497-502, 発行日 2002-12-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Angiotensin converting enzyme (ACE) inhibitors are effective in the treatment of heart failure, although their pharmacological and precise hemodynamic effects have not yet been well defined in pediatric patients. We attempted to determine an optimal dose of Cilazapril to clarify its cardiovascular effects. We first looked to determine the optimal dose in 20 patients. We found that a dose of 0.04 mg/kg/day reduced ACE activity to less than 50% of baseline measurement, which established this as the optimal dose for pediatric patients. In using the optimal dose as stated above, its short-term effects were studied by means of echocardiography on 13 children with heart failure. It was found that the end-systolic wall stress was significantly reduced, which resulted in an increase in LV pump function. Then, we studied the long-term effect of Cilazapril on 12 children with heart failure. At 1 to 5.3 years after administration, LV pump function had increased and LV diastolic dimension was reduced compared to the baseline data. The cardiovascular effects seen in the short term were maintained for several years and cardiomegaly did not appear in spite of heart failure. The ACE inhibitor, Cilazapril, is therefore an effective medicine for children with heart failure. | |||||
著者所属 | ||||||
東京女子医科大学日本心臓血圧研究所循環器小児科 |