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培養線維芽細胞シート移植による新規気漏閉鎖術(21世紀COE記念シンポジウム再生医療の最前線,東京女子医科大学学会第71回総会)
http://hdl.handle.net/10470/27132
http://hdl.handle.net/10470/27132feea3d2b-86fb-4594-b644-1ef92d1e8a8f
名前 / ファイル | ライセンス | アクション |
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KJ00006018108.pdf (1.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | 培養線維芽細胞シート移植による新規気漏閉鎖術(21世紀COE記念シンポジウム再生医療の最前線,東京女子医科大学学会第71回総会) | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | A Novel Method to Seal Intractable Air Leakage Utilizing Autologous Dermal Fibroblast Sheets Fabricated with Cell Sheet Engineering(The 21st COE Symposium on the Frontier Regenerative Medicine) | |||||
著者名 |
神崎, 正人
× 神崎, 正人× 大貫, 恭正× 大和, 雅之× 岡野, 光夫 |
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著者別名 | ||||||
姓名 | KANZAKI, Masato | |||||
著者別名 | ||||||
姓名 | ONUKI, Takamasa | |||||
著者別名 | ||||||
姓名 | YAMATO, Masayuki | |||||
著者別名 | ||||||
姓名 | OKANO, Teruo | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 76, 号 4, p. 184-189, 発行日 2006-04 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | One of the most troublesome complications is intraoperative or prolonged air leakage from the lung. Advances in surgical techniques, including the use of stapling devices, have minimized but not abolished such complications. Lung parenchymal defects are difficult to suture often both damages the normal lung and fails to stop the air leakage. Current methods including the use of various sealants, are ineffective in the closure of intraoperative air leaks, resulting in a increased patient morbidity, delayed removal of thoracic tubes, and prolonged hospitalization. We present the development of a novel lung air leak sealant using tissue engineered cell sheets. Cell sheets immediately and permanently seal air leaks in a dynamic function that allows for the extensive tissue contraction and expansion involved in respiration, with no postoperative recurrences. Moreover, we demonstrate that host mesothelial cells can migrate to cover the transplanted cells sheets, thereby confirming excellent biocompatibility and integration with host tissues. Finally, we show the use of skin fibroblasts as an effective autologous cell source that can be easily applied. This study shows for the first time, the development of an immediate and permanent lung air leak sealant, suitable for future clinical applications. | |||||
著者所属 | ||||||
東京女子医科大学医学部第一外科学 | ||||||
著者所属 | ||||||
東京女子医科大学医学部第一外科学 | ||||||
著者所属 | ||||||
東京女子医科大学先端生命医科学研究所 | ||||||
著者所属 | ||||||
東京女子医科大学先端生命医科学研究所 | ||||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | air leak | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | cell sheet | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | fibroblast | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | autologous cell | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | sealant |