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インターフェロン治療中止にもかかわらずバセドウ病を発症した一例
http://hdl.handle.net/10470/27959
http://hdl.handle.net/10470/2795996ec0620-f604-488c-acde-ad730ebd33f2
名前 / ファイル | ライセンス | アクション |
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KJ00006014925.pdf (475.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | インターフェロン治療中止にもかかわらずバセドウ病を発症した一例 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | A Case of Graves' Disease That Developed After Withdrawal of Interferon Therapy for HCV Hepatitis | |||||
著者名 |
大和田, 里奈
× 大和田, 里奈× 大久保, 梨紗× 磯崎, 収× 田中, 聡× 鳥居, 信之× 高野, 加寿恵 |
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著者別名 | ||||||
姓名 | OHWADA, Rina | |||||
著者別名 | ||||||
姓名 | OKUBO, Risa | |||||
著者別名 | ||||||
姓名 | ISOZAKI, Osamu | |||||
著者別名 | ||||||
姓名 | TANAKA, Satoshi | |||||
著者別名 | ||||||
姓名 | TORII, Nobuyuki | |||||
著者別名 | ||||||
姓名 | TAKANO, Kazue | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 78, 号 7, p. 306-309, 発行日 2008-07 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Interferon (IFN)-α has been reported to have several adverse effects including thyroid dysfunction. We herein report a case of Graves' disease that developed after withdrawal of PEG-INF-α therapy. The patient was a 62-year-old woman who was admitted to our department for radioactive iodine therapy (RIT) for Graves' disease. Eleven years earlier, when the diagnosis of chronic hepatitis C had been confirmed, PEG-INF therapy with ribavirin was initiated, but therapy was withdrawn after three months because of severe cough and thrombocytopenia (platelets < 70,000/mm^3). She developed palpitations soon after withdrawal of therapy, and pitting edema was evident after 2 months. At that time her thyroid hormone levels were elevated and Graves' disease was diagnosed. Thiamazole was initiated, but this was changed to propyluracil (PTU) because of liver dysfunction. However, PTU did not ameliorate the thyrotoxicosis. Therefore, RIT was performed after admission to our department. Recent studies have demonstrated that IFN induces thyroid dysfunction in 15% of patients with hepatitis C. Female gender, a family history of thyroid disease, presence of thyroid autoantibodies, and HCV infection are risk factors for thyroid dysfunction. In the present case, we have no data about thyroid autoantibodies such as TRAb or TSAb before IFN therapy, but this therapy may have exacerbated subclinical Graves' disease in this patient. | |||||
著者所属 | ||||||
東京女子医科大学内分泌疾患総合医療センター内科 | ||||||
著者所属 | ||||||
東京女子医科大学卒後臨床研修センター | ||||||
著者所属 | ||||||
東京女子医科大学内分泌疾患総合医療センター内科 | ||||||
著者所属 | ||||||
東京女子医科大学内分泌疾患総合医療センター内科 | ||||||
著者所属 | ||||||
東京女子医科大学卒後臨床研修センター | ||||||
著者所属 | ||||||
東京女子医科大学内分泌疾患総合医療センター内科:東京女子医科大学卒後臨床研修センター | ||||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | Graves' disease | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | Interferon α | |||||
著者キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chronic hepatitis C |