An Updated Focus on Quadruplex Structures as Potential Therapeutic Targets in Cancer
Metadatos
Mostrar el registro completo del ítemAutor
Sánchez Martin, Victoria; López Pujante, Carmen; Soriano Rodríguez, Miguel; García Salcedo, José A.Editorial
Mdpi
Materia
DNA G-quadruplex RNA G-quadruplex i-Motif Cancer
Fecha
2020-11-24Referencia bibliográfica
Sanchez-Martin, V., Lopez-Pujante, C., Soriano-Rodriguez, M., & Garcia-Salcedo, J. A. (2020). An Updated Focus on Quadruplex Structures as Potential Therapeutic Targets in Cancer. International Journal of Molecular Sciences, 21(23), 8900. [doi:10.3390/ijms21238900]
Patrocinador
3TR, IMI2 H2020-JTI538 IMI2-2018; Instituto de Salud Carlos III AC18/00008; Government of Spain FPU16/05822Resumen
Non-canonical, four-stranded nucleic acids secondary structures are present within
regulatory regions in the human genome and transcriptome. To date, these quadruplex structures
include both DNA and RNA G-quadruplexes, formed in guanine-rich sequences, and i-Motifs, found
in cytosine-rich sequences, as their counterparts. Quadruplexes have been extensively associated
with cancer, playing an important role in telomere maintenance and control of genetic expression of
several oncogenes and tumor suppressors. Therefore, quadruplex structures are considered attractive
molecular targets for cancer therapeutics with novel mechanisms of action. In this review, we provide
a general overview about recent research on the implications of quadruplex structures in cancer,
firstly gathering together DNA G-quadruplexes, RNA G-quadruplexes as well as DNA i-Motifs.