Mycophenolate Improves Brain–Gut Axis Inducing Remodeling of Gut Microbiota in DOCA-Salt Hypertensive Rats
Metadatos
Mostrar el registro completo del ítemAutor
Robles Vera, Iñaki; de la Visitación, Néstor; Sánchez, Manuel; Gómez Guzmán, Manuel; Jiménez Moleón, Rosario; Moleón Moya, Javier; González Correa, Cristina; Romero Pérez, Miguel; Duarte Pérez, Juan ManuelEditorial
Mdpi
Materia
Mycophenolate Gut dysbiosis Hypertension Oxidative stress Inflammation (Deoxycorticosterone acetate) DOCA-salt model
Fecha
2020-11-28Referencia bibliográfica
García-García, G., Fernández-Álvarez, F., Cabeza, L., Delgado, Á. V., Melguizo, C., Prados, J. C., & Arias, J. L. (2020). Gemcitabine-Loaded Magnetically Responsive Poly (ε-caprolactone) Nanoparticles against Breast Cancer. Polymers, 12(12), 2790. [doi:10.3390/antiox9121199]
Patrocinador
Comisión Interministerial de Ciencia y Tecnología, Ministerio de Economía y competitividad SAF2017-84894-R; Junta de Andalucía CTS-164; European Union (EU); Ministerio de Economía y Competitividad, Instituto de Salud Carlos III (CIBER-CV), Spain; United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Heart Lung & Blood Institute (NHLBI) HL102033; European Union (Fondo Europeo de Desarrollo Regional, FEDER, "FEDER una manera de hacer Europa")Resumen
Microbiota is involved in the host blood pressure (BP) regulation. The immunosuppressive
drug mofetil mycophenolate (MMF) ameliorates hypertension. The present study analyzed whether
MMF improves dysbiosis in mineralocorticoid-induced hypertension. MaleWistar rats were assigned
to three groups: untreated (CTR), deoxycorticosterone acetate (DOCA)-salt, and DOCA treated
with MMF for 4 weeks. MMF treatment reduced systolic BP, improved endothelial dysfunction,
and reduced oxidative stress and inflammation in aorta. A clear separation in the gut bacterial
community between CTR andDOCAgroups was found, whereas the cluster belonging toDOCA-MMF
group was found to be intermixed. No changes were found at the phylum level among all experimental
groups. MMF restored the elevation in lactate-producing bacteria found in DOCA-salt joined to an
increase in the acetate-producing bacteria. MMF restored the percentage of anaerobic bacteria in the
DOCA-salt group to values similar to control rats. The improvement of gut dysbiosis was associated
with an enhanced colonic integrity and a decreased sympathetic drive in the gut. MMF inhibited
neuroinflammation in the paraventricular nuclei in the hypothalamus. This study demonstrates for
the first time that MMF reduces gut dysbiosis in DOCA-salt hypertension models. This e ect seems
to be related to its capacity to improve gut integrity due to reduced sympathetic drive in the gut
associated with reduced brain neuroinflammation.