Osteoporosis in patients with subclinical hypothyroidism treated with thyroid hormone
Entity
UAM. Departamento de CirugíaPublisher
CIC Edizioni InternazionaliDate
2011Citation
Clinical Cases in Mineral and Bone Metabolism 8.3 (2011): 44-48ISSN
1724-8914 (print); 1971-3266 (online)Subjects
Osteoporosis; Hypothyroidism; Hormones thyroids; MedicinaAbstract
Objective: to estimate the prevalence of osteoporosis in patients
being treated with thyroid hormone.
Method: cross-sectional retrospective study of primary care
patients.
Experimental Group: patients diagnosed with subclinical hypothyroidism
receiving thyroid hormone replacement therapy.
Control Group: patients not receiving replacement therapy.
Once the sample was selected its members were summoned
to complete a clinical questionnaire and undergo a bone density
scan with a validated measuring device.
The description of qualitative data was done in absolute frequencies
and percentages and that of the quantitative data
as mean standard deviation, median.
In the comparison of qualitative data between groups we used
the Chi-square test and contingency tables by rearranging the
percentages of several variables.
Results: 182 patients were studied (112 experimental and 70
control), diagnosed with subclinical hypothyroidism
Objective: to estimate the prevalence of osteoporosis in patients
being treated with thyroid hormone.
Method: cross-sectional retrospective study of primary care
patients.
Experimental Group: patients diagnosed with subclinical hypothyroidism
receiving thyroid hormone replacement therapy.
Control Group: patients not receiving replacement therapy.
Once the sample was selected its members were summoned
to complete a clinical questionnaire and undergo a bone density
scan with a validated measuring device.
The description of qualitative data was done in absolute frequencies
and percentages and that of the quantitative data
as mean standard deviation, median.
In the comparison of qualitative data between groups we used
the Chi-square test and contingency tables by rearranging the
percentages of several variables.
Results: 182 patients were studied (112 experimental and 70
control), diagnosed with subclinical hypothyroidism. The average
age at diagnosis was 42.5 and 41.2 years, respectively.
32.7% and 33.2% were smokers. In the experimental group
the coexistence of two or more cardiovascular risk factors
was detected in 5.7% of the patients. Mean TSH was 6.67 mU/L,
mean freeT4 1,04 ng/dl.
67% of the patients studied had some level of bone loss: 87%
osteopenia and 14% osteoporosis. 56% of those suffering from
bone less were women. With regard to the size of the thyroid
hormone treatment, only 12% received 150 μg/day or more.
61% had received treatment for between 5 and 10 years and
19.5% for more than 10 years.
Conclusions: there is a high prevalence of bone loss in patients
with subclinical hypothyroidism treated with exogenous
thyroxin.
Files in this item
Google Scholar:Tárraga López, Pedro J.
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Frias López, Carmen
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Naharro de Mora, Francisco
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Rodríguez Montes, José Antonio
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Solera Albero, Juan
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Naharro Mañez, Antonio
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Galvez Casas, Arancha
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