Diagnostic potential of circulating cell-free DNA in patients needing mechanical ventilation: Promises and challenges
Entity
UAM. Departamento de Farmacología; UAM. Departamento de MedicinaPublisher
BioMed CentralDate
2011-09-12Citation
10.1186/cc10365
Critical Care 15 (2011):187
ISSN
1364-8535DOI
10.1186/cc10365Editor's Version
http://ccforum.com/content/15/5/187Subjects
cf-DNA; Mechanical ventilation; MedicinaRights
© 2011 BioMed Central LtdAbstract
Circulating cell-free DNA (cf-DNA) mainly comes from
apoptotic cells and can refl ect the extent of cellular
damage. Increased plasma levels of cf-DNA have been
found in many acute disorders, including septic and
clinically ill patients, and usually correlate well with
clinical outcome. Acute respiratory failure, the most
frequent organ failure in ICU patients, can be related to
various acute diseases that may cause cell death and
release of DNA into the bloodstream. In a recent issue
of Critical Care, Okkonen and colleagues evaluate levels
of cf-DNA in plasma as a prognostic marker in patients
needing mechanical ventilation. They report that
plasma cf-DNA was higher than normal in patients with
mechanical ventilation, and even higher in patients
who eventually died compared to survivors. However,
its usefulness as a death predictor may be limited in
the heterogeneous group of mechanically ventilated
patients, probably due to confounding eff ects of comorbidities,
among other factors.
Files in this item
Google Scholar:Arnalich Fernández, Francisco
-
López-Collazo, Eduardo
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Montiel López, Carmen
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