Association of CD247 polymorphisms with rheumatoid arthritis: a replication study and a meta-analysis
Entity
UAM. Departamento de MedicinaPublisher
Public Library of ScienceDate
2013-07-05Citation
10.1371/journal.pone.0068295
Plos One 8.7 (2013): e68295
ISSN
1932-6203 (online)DOI
10.1371/journal.pone.0068295Funded by
This work was supported by two Spanish grants from RETICS Program, RD12/0009/0004 (RIER) from Instituto de Salud Carlos III (ISCIII), within the VI PN de I+D+i 2008–2011 (FEDER) and also by grants from the European IMI BTCure Program. MT was supported by Ministerio Economía y Competividad through the program Juan de la Cierva (JCI-2010-08227)Subjects
Antigens; Arthritis; Genotype; Polymorphism; Rheumatoid; MedicinaRights
© 2013 Teruel et al.Abstract
Given the role of CD247 in the response of the T cells, its entailment in autoimmune diseases and in order to better clarify the role of this gene in RA susceptibility, we aimed to analyze CD247 gene variants previously associated with other autoimmune diseases (rs1052237, rs2056626 and rs864537) in a large independent European Caucasian population. However, no evidence of association was found for the analyzed CD247 single-nucleotide polymorphisms (SNPs) with RA and with the presence/absence of anti-cyclic citrullinated polypeptide. We performed a meta-analysis including previously published GWAS data from the rs864537 variant, revealing an overall genome-wide significant association between this CD247 SNP and RA with anti-CCP (OR = 0.90, CI 95% = 0.87-0.93, Poverall = 2.1×10-10). Our results show for first time a GWAS-level association between this CD247 polymorphism and RA risk
Files in this item
Google Scholar:Teruel, María
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McKinney, Cushla Z.
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Balsa Criado, Alejandro
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Pascual-Salcedo, Dora
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Rodríguez-Rodríguez, Luis
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Ortíz, Ana María
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Gómez-Vaquero, Carmen
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González-Gay, Miguel Ángel
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Smith, Malcolm Douglas
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Witte, Torsten N.
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Merriman, Tony R.
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Lie, Benedicte A.
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Martín, Javier E.
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