Orthopedic surgery is possible in hemophilic patients with inhibitors
Author
Rodríguez Merchán, E. CarlosEntity
UAM. Departamento de CirugíaPublisher
Frontline Medical CommunicationsDate
2012-12Citation
The American Journal of Orthopedics 41.12 (2012): 570-574ISSN
1078-4519 (print); 1934-3418 (online)Subjects
Haemophilia; Haemophilic arthropathy; Inhibitors; Orthopaedic surgery; Prevention; Prophylaxis; MedicinaNote
Este artículo está disponible en la página web de la revista: http://www.amjorthopedics.comRights
© Frontline Medical Communications Inc. 2012Abstract
Hemophilia is an inherited recessive sex-linked bleeding
disorder. An insufficiency of coagulation factor VIII
produces hemophilia A, and lack of factor IX causes
hemophilia B. Prevention and management of the disease
require intravenous infusion of the deficient factor.
Worldwide, hemophilia affects approximately 600,000
people, 20% of whom develop antibodies against the
deficient coagulation factor. Hemophilic patients with
inhibitors present with multiarticular joint degeneration
(hemophilic arthropathy) secondary to recurrent
hemarthroses. The availability of activated prothrombin
complex concentrates and activated recombinant factor
VII allows hemophilic patients with high inhibitor titers to
undergo elective orthopedic surgery with a high expectation
of success, and thorough individual case analysis
by a multidisciplinary team allows surgeons to obtain
satisfactory results. However, the rate of potential complications
must not be underestimated
Files in this item
Google Scholar:Rodríguez Merchán, E. Carlos
This item appears in the following Collection(s)
Related items
Showing items related by title, author, creator and subject.
-
KRAS p.G12C mutation occurs in 1% of EGFR-mutated advanced non-small-cell lung cancer patients progressing on a first-line treatment with a tyrosine kinase inhibitor
Serna-Blasco, R.; Sánchez-Herrero, E.; Sanz-Moreno, S.; Rodriguez-Festa, A.; García-Veros, E.; Casarrubios, M.; Sierra-Rodero, B.; Laza-Briviesca, R.; Cruz-Bermúdez, A.; Mielgo-Rubio, X.; Sánchez-Hernández, A.; Uribelarrea, E. A.; Calvo de Juan, Virginia; Romero, A.; Provencio Pulla, Mariano
2021-10-01