Asymmetric vinylogous Mukaiyama aldol reaction of isatins under bifunctional organocatalysis: Enantioselective synthesis of substituted 3-hydroxy-2-oxindoles
Entity
UAM. Departamento de Química OrgánicaPublisher
The Royal Society of ChemistryDate
2018-02-20Citation
10.1039/c8cc00759d
Chemical Communication 54.22 (2018): 2781-2784
ISSN
1359-7345 (print); 1364-548X (online)DOI
10.1039/c8cc00759dFunded by
The Spanish Government (CTQ2015-64561-R) is acknowledged. V. L.-M. thanks the Autonomous university of Madrid for a predoctoral fellowship (FPI-UAM). J. A. F.-S. thanks the Spanish Government for a Juan de la Cierva ContractProject
Gobierno de Epaña. CTQ2015-64561-REditor's Version
https://doi.org/10.1039/C8CC00759DSubjects
Bifunctional organocatalysis; Chemical interaction; 3 hydroxy 2 oxindole; Oxindole; Mukaiyama reaction; QuímicaRights
© 2018 The Royal Society of ChemistryAbstract
A highly enantioselective organocatalytic vinylogous Mukaiyama aldol reaction of silyloxy dienes and isatins under bifunctional organocatalysis is presented. Substituted 3-hydroxy-2-oxindoles are synthesised in good yields and enantioselectivities. These synthetic intermediates are used for the construction of more complex molecules with biological properties such as the formal synthesis of a CB2 agonist presented
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Google Scholar:Laina-Martín, Víctor
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Humbrías-Martín, Jorge
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Fernández Salas, José Antonio
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Alemán Lara, José Julián
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