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Fe-bLf nanoformulation targets survivin to kill colon cancer stem cells and maintains absorption of iron, calcium and zinc

Version 2 2024-06-07, 00:33
Version 1 2015-03-17, 15:10
journal contribution
posted on 2024-06-07, 00:33 authored by JR Kanwar, V Mahidhara, K Roy, S Sasidharan, S Krishnakumar, N Prasad, R Sehgal, RK Kanwar
To validate the anticancer efficacy of alginate-enclosed, chitosan-conjugated, calcium phosphate, iron-saturated bovine lactoferrin (Fe-bLf) nanocarriers/nanocapsules (NCs) with improved sustained release and ability to induce apoptosis by downregulating survivin, as well as cancer stem cells.

History

Journal

Nanomedicine

Volume

10

Pagination

35-55

Location

London, United Kingdom

Publisher DOI

eISSN

1748-6963

Language

eng

Author URL

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2014, Future Medicine

Issue

1

Publisher

Future Medicine

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    Research Publications

    Categories

    Keywords

    Fe-bLfabsorptioniron metabolismmiRNAnanocarriers/nanocapsulesnanotoxicityoral deliverystem cellsurvivinxenograftScience & TechnologyLife Sciences & BiomedicineBiotechnology & Applied MicrobiologyNanoscience & NanotechnologyScience & Technology - Other TopicsnanocarriersnanocapsulesANTIOXIDANT ENZYME-ACTIVITIESGUT EPITHELIAL-CELLSTRANSFERRIN RECEPTOROXIDATIVE STRESSDRUG-DELIVERYTRANSPORTER 1CACO-2 CELLSNUDE-MICEIN-VITROSchool of Medicine119999 Medical and Health Sciences not elsewhere classified929999 Health not elsewhere classified

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    All Rights Reserved

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