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Expression of anti-viral shRNA molecules in transgenic zebrafish

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thesis
posted on 2015-04-01, 00:00 authored by B Clarke
Development of transgenic zebrafish specifically resistant to Viral Hemorrhagic Septicemia Virus mediated by short-hairpin RNA interference. Introduction of shRNAs by Tol2 transgenisis in to zebrafish overwhelmed multiple facets of the endogenous microRNA pathway including Exportin-5 and Argonaute-2 and prevented normal zebrafish development.

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Pagination

xxiv, 228 pages : illustrations, tables

Open access

  • Yes

Material type

thesis

Resource type

thesis

Language

eng

Degree type

Research doctorate

Degree name

Ph.D.

Copyright notice

The Author. All Rights Reserved

Editor/Contributor(s)

C Ward Alister C.

Faculty

Faculty of Health

School

School of Medicine

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    Theses

    Categories

    Keywords

    transgenic zebrafishviral hemorrhagic septicemia virusshort-hairpin RNA interferenceTransgenesisAgricultural Marine BiotechnologyGenetically Modified Animals

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    All Rights Reserved

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