Epidermal growth factor receptor expression in different subtypes of oral lichenoid disease
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2014
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Abstract
The oral lichenoid disease (OLD) includes different chronic inflammatory processes such as oral lichen planus
(OLP) and oral lichenoid lesions (OLL), both entities with controversial diagnosis and malignant potential. Epidermal
growth factor receptor (EFGR) is an important oral carcinogenesis biomarker and overexpressed in several
oral potentially malignant disorders.
Objectives: To analyze the EGFR expression in the OLD to find differences between OLP and OLL, and to correlate
it with the main clinical and pathological features.
Material and Methods: Forty-four OLD cases were studied and classified according to their clinical (Group C1:
only papular lesions / Group C2: papular and other lesions) and histopathological features (Group HT: OLP-typical
/ Group HC: OLP-compatible) based in previous published criteria. Standard immunohistochemical identification
of EGFR protein was performed. Comparative and descriptive statistical analyses were performed.
Results: Thirty-five cases (79.5%) showed EGFR overexpression without significant differences between clinical
and histopathological groups (p<0.05). Histological groups showed significant differences in the EGFR expression
pattern (p=0.016).
Conlusions: All OLD samples showed high EGFR expression. The type of clinical lesion was not related with
EGFR expression; however, there are diff erences in the EGFR expression pattern between histological groups that
may be related with a different biological profile and malignant risk.
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Cortés Ramírez, Dionisio Alejandro ; Rodríguez Tojo, María José ; Coca Meneses, Juan Carlos ; Marichalar Mendia, Xabier ; Aguirre Urízar, José Manuel. Epidermal growth factor receptor expression in different subtypes of oral lichenoid disease. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2014, Vol. 19, No. 5: 451-458