Cyclin D1 and Ki-67 expression correlates to tumor staging in tongue squamous cell carcinoma
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2015
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Abstract
Background: The immunohistochemical expression of Cyclin D1 and Ki-67 were analyzed in tongue squamous
cell carcinomas (SCC), relating them to the clinical and morphological exhibition of these tumors.
Material and Methods: Twenty-nine patients fulfilled the inclusion criteria; clinical data included gender, age, ethnicity and use of licit drugs such as alcohol and tobacco. The TNM staging and histopathological differentiation
grading was assessed for each case. In addition, T1 patients were gathered with T2 patients; and T3 patients were
gathered with T4 patients to assemble two distinct groups: (T1/T2) and (T3/T4).
Results: The mean follow-up time was 24 months and 30% of the patients died as a consequence of the disease,
while 23.3% lived with the disease and 46.7% lived lesion-free. T1 and T2 tumors showed statistically lesser Ki-67
and Cyclin D1 staining when compared to T3 and T4 tumors.
Conclusions: Ki-67 and Cyclin D1 pose as auxiliary tools when determining the progression of tongue SCC at the
time of diagnosis.
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Guimarães, Eduardo-Pereira ; de Carli, Marina-Lara ; Sperandio, Felipe-Fornias ; Hanemann, João-Adolfo-Costa ; Pereira, Alessandro-Antônio-Costa. Cyclin D1 and Ki-67 expression correlates to tumor staging in tongue squamous cell carcinoma. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 6: 4-