腎不全におけるエンドセリンの検討

Abstract

The role of Endothelin (ET) in renal failure was evaluated by experimental study using rats (study 1) and clinical study (study 2). In study 1, the change of plasma ET level in renal failure was evaluated in two groups of rats. Group 1 consists of sham operation for left kidney and right nephrectomy, and group 2 consists of 60 minutes warm ischemic damaged left kidney and right nephrectomy. In group 2, plasma ET level increased and was followed with the renal insufficiency. In study 2, the comparison of plasma ET level between the chronic renal failure patients treated with hemodialysis (HD) and those treated with renal transplantation (Tx) was demonstrated. In transplanted patients, periodical change of plasma ET level after renal transplantation was demonstrated. The plasma ET level in HD patients is significantly higher than that of Tx patients. The change in plasma ET level corresponded to renal function. In Tx patients, plasma ET level decreased periodically, followed by the improving of renal function. The results of this study suggest that measurement of plasma ET level is useful as a marker of renal function.