IN VITRO STUDIES ON THE ANTI ICANCER AND ANTIMICROBIAL EFFECT OF Trigonella foenum graecum L Cinnamomum verum J Presl AND Carica papaya L EXTRACTS IN ORAL SQUAMOUS CELL CARRCINOMA CELL LINE AND SELECTED MICROBIAL STRAINS

Abstract

Oral squamous cell carcinoma the sixth most common neoplasm of the head and neck region is a disease with high morbidity and mortality There is substantial evidence demonstrating the role of reactive oxygen species and microorganisms in carcinogenesis Apoptosis and cell cycle dysregulation are the key features of oral squamous cell carcinoma Hence anticancer agents that could induce apoptosis and cause cell cycle arrest would aid in treatment of the condition Although surgery chemotherapy and radiotherapy are the measures for management of the disease the five year survival rate has not seen much improvement In addition to surgery a therapeutic approach that would be cost effective and would possess antioxidant antimicrobial and anticancer properties would not only aid in management of the disease but also aid in biochemoprevention thereby reducing Cancer burden in our nation Recently screening of herbs for antioxidant antimicrobial and anticancer properties have been the subject of research for cancer management With this background we have made an attempt to study the antioxidant potential anticancer and antimicrobial effects of fenugreek seed Trigonella foenum graecum L cinnamon bark Cinnamomum verum J Presl bark and papaya leaf and seed Carica papaya L extracts in oral squamous cell carcinoma cell line and on selected microbial strains The anticancer effects of the standard cisplatin and the active compounds like trigonelline hydrochloride cinnamaldehyde 4 hydroxy cinnamic acid eugenol benzyl isothiocyanate of the extracts were also assessed In the present study Trigonella foenum graecum L seeds Cinnamomum verum J Presl bark Carica papaya L leaves of male and female plant and Carica papaya L seeds showed significant in vitro antioxidant activity Trigonella foenum graecum L seeds Cinnamomum verum J Presl bark Carica papaya L leaves of male and female plant and Carica papaya L seeds exhibited mild antimicrobial activity against Streptococcus mutans Trigonella foenum graecum L seeds Cinnamomum verum J Presl bar