Dessigning and Development of Drug studies on the Functional Consequences of Anti Apoptosis gene in Cancer

Abstract

Cancer is one of the leading diseases that is affecting large number of newlinepopulation in the world. Damage in the Apoptotic pathway may leads to the newlinecontinuous growth of the cells which in turn leads to cause of cancer. Now-a-days newlinevarious studies have been done on the apoptotic signaling pathway which acts a newlinenovel drug target for cancer. Chemotherapeutic drug resistance is a major clinical newlineproblem and an important cause of treatment failure in cancer. One of the important newlinegoals of molecular oncology is to identify the underlying drug resistance newlinemechanisms, with the prospect that more effective and novel therapies for cancer newlinecan be developed. Several mechanisms have been found to cause resistance to newlinechemotherapeutic agents in cancer cells in vitro. Defects in apoptotic signaling in newlinemalignant cells contribute to the drug resistance in various cancer types. newlineFurthermore, death receptor- mediated apoptosis is deficient in some drug resistant newlinecancer cells. newlineSo considering the antiapoptotic protein mechanisms for design more newlineeffective strategies for cancer treatment is important. This study has a key focus on newlinethe antiapoptotic protein and its role in cancer biology.CDC25A, BCL2 and Cellular newlineFLICE (FADD-like IL-1beta-converting enzyme)-inhibitory protein (cFLIP) is a newlinemajor resistance factor and critical anti-apoptotic regulator it blocks this death signal newlinefrom entering the cell. There are currently no drugs which can specifically inhibit newlinethe ability of this protein to suppress cell death. We have considered protein newlinestructure of cFLIP for sequence analysis. We obtained some compound for which newlinewe perform the docking studies. From these we select the compound for synthesis newlineand anticancer activity. It has been studied that various synthetic and natural newlinecompounds are showing activity against the cFLIP protein which is one of the most newlineimportant drug target in the death receptor mediated apoptosis pathway. It has also newlinebeen studied that these synthetic compounds not only inhibit the cFLIP function but newlinethey in turn can inhibit the