Cardiovascular function after long-term bed rest
Author: Spaak, Jonas
Date: 2001-09-21
Location: Fysiologens föreläsningssal, Karolinska Institutet
Time: 9.00
Department: Institutionen för fysiologi och farmakologi / Department of Physiology and Pharmacology
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thesis.pdf (744.7Kb)
Abstract
On earth, daily activities involve standing, changes of posture and various types of muscle action, all of which challenge the cardiovascular regulation. Removal of the orthostatic stress for a longer period, as during spaceflight or head-down tilt bed rest, consistently results in cardiovascular deconditioning.
The principal aim of this thesis was to improve the understanding of cardiovascular deconditioning, as reflected in altered structure and control after long-term spaceflight and bed rest. Apart from an initial methodological study, all results are based on two head-down tilt bed rest experiments with durations of 42 and 120 clays, and on five spaceflights with durations of 6 to 13 months.
In the initial study, the separate effects of voluntary motor activation and muscle chemoreflex activation on arterial baroreflexes in healthy young men were examined. It was found that the elevation of arterial blood pressure is mainly caused by muscle ischemia, whereas the heart rate response is entirely due to somatomotor activation.
These conclusions provided a basis for the following study, aiming to characterized the cardiovascular responses to isometric muscle action during and after spaceflight and after bed rest. The responses to isometric lower arm contraction were determined, and it was concluded that impaired cardiovascular responses to isometric muscle action do contribute to the cardiovascular deconditioning after spaceflight and bed rest.
In the two bed rest studies, cardiac output (CO) and stroke volume (SV) were determined, and marked reductions were found in both CO and SV, in both supine and upright posture, during rest and during 50 watt pedalling. The time-course of the deconditioning and recovery of SV in the different conditions indicates that SV reductions in the upright posture after bed rest are mainly due to an impaired preload, and recuperate swiftly as plasma volume recovers. On the other hand, SV reductions in the supine posture during exercise, showed a slow, progressive decline during bed rest, and a protracted recovery after bed rest, strongly suggesting an altered cardiac morphology and probably a decreased heart size.
In the 120-day bed rest study, impairments in blood pressure control during rest and exercise were also assessed. It was found that bed rest causes markedly increased blood pressure deviations during rapid tilts at exercise, indicating impaired reflex and/or effector organ function. Furthermore, it was found that bed rest causes attenuated baroreflex sensitivity for chronotropic responses to arterial pressure stimuli, although this appears to be of modest functional significance.
The finding of a reduced degree of mechanical interaction between the two ventricles provided indirect evidence of reduced cardiac size during and after bed rest. Hemodynamic and baroreflex impairments had similar time courses, suggesting that reductions of cardiac size may be a common denominator for both of these types of hemodynamic and baroreflex impairments. Despite these changes, the ability to maintain the arterial blood pressure during steady state conditions was found to be preserved after bed rest.
The principal aim of this thesis was to improve the understanding of cardiovascular deconditioning, as reflected in altered structure and control after long-term spaceflight and bed rest. Apart from an initial methodological study, all results are based on two head-down tilt bed rest experiments with durations of 42 and 120 clays, and on five spaceflights with durations of 6 to 13 months.
In the initial study, the separate effects of voluntary motor activation and muscle chemoreflex activation on arterial baroreflexes in healthy young men were examined. It was found that the elevation of arterial blood pressure is mainly caused by muscle ischemia, whereas the heart rate response is entirely due to somatomotor activation.
These conclusions provided a basis for the following study, aiming to characterized the cardiovascular responses to isometric muscle action during and after spaceflight and after bed rest. The responses to isometric lower arm contraction were determined, and it was concluded that impaired cardiovascular responses to isometric muscle action do contribute to the cardiovascular deconditioning after spaceflight and bed rest.
In the two bed rest studies, cardiac output (CO) and stroke volume (SV) were determined, and marked reductions were found in both CO and SV, in both supine and upright posture, during rest and during 50 watt pedalling. The time-course of the deconditioning and recovery of SV in the different conditions indicates that SV reductions in the upright posture after bed rest are mainly due to an impaired preload, and recuperate swiftly as plasma volume recovers. On the other hand, SV reductions in the supine posture during exercise, showed a slow, progressive decline during bed rest, and a protracted recovery after bed rest, strongly suggesting an altered cardiac morphology and probably a decreased heart size.
In the 120-day bed rest study, impairments in blood pressure control during rest and exercise were also assessed. It was found that bed rest causes markedly increased blood pressure deviations during rapid tilts at exercise, indicating impaired reflex and/or effector organ function. Furthermore, it was found that bed rest causes attenuated baroreflex sensitivity for chronotropic responses to arterial pressure stimuli, although this appears to be of modest functional significance.
The finding of a reduced degree of mechanical interaction between the two ventricles provided indirect evidence of reduced cardiac size during and after bed rest. Hemodynamic and baroreflex impairments had similar time courses, suggesting that reductions of cardiac size may be a common denominator for both of these types of hemodynamic and baroreflex impairments. Despite these changes, the ability to maintain the arterial blood pressure during steady state conditions was found to be preserved after bed rest.
List of papers:
I. Spaak J, Sundblad P, Linnarsson D (1998). "Human carotid baroflex during isometric lower arm contraction and ischemia." American Journal of Physiology 275(3 Pt 2): H940-5
Pubmed
II. Spaak J, Sundblad P, Linnarsson D (2001). "Impaired pressor response after spaceflight and bed rest: evidence for cardiovascular dysfunction. " Eur J Appl Physiol 85(1-2): 49-55
Pubmed
III. Sundblad P, Spaak J, Linnarsson D (2000). "Cardiovascular responses to upright and supine exercise in humans after 6 weeks of head-down tilt (-6 degrees). " Eur J Appl Physiol 83(4 -5): 303-9
Pubmed
IV. Spaak J, Montmerle S, Sundbla P, Linnarsson D (2001). "Stroke volume during rest and exercise after 120 days bed rest." (Manuscript)
V. Linnarsson D, Sundblad P, Spaak J (2001). "Hemodynamic and baroreflex to rapid posture changes after prolonged bed rest." (Manuscript)
I. Spaak J, Sundblad P, Linnarsson D (1998). "Human carotid baroflex during isometric lower arm contraction and ischemia." American Journal of Physiology 275(3 Pt 2): H940-5
Pubmed
II. Spaak J, Sundblad P, Linnarsson D (2001). "Impaired pressor response after spaceflight and bed rest: evidence for cardiovascular dysfunction. " Eur J Appl Physiol 85(1-2): 49-55
Pubmed
III. Sundblad P, Spaak J, Linnarsson D (2000). "Cardiovascular responses to upright and supine exercise in humans after 6 weeks of head-down tilt (-6 degrees). " Eur J Appl Physiol 83(4 -5): 303-9
Pubmed
IV. Spaak J, Montmerle S, Sundbla P, Linnarsson D (2001). "Stroke volume during rest and exercise after 120 days bed rest." (Manuscript)
V. Linnarsson D, Sundblad P, Spaak J (2001). "Hemodynamic and baroreflex to rapid posture changes after prolonged bed rest." (Manuscript)
Issue date: 2001-08-31
Rights:
Publication year: 2001
ISBN: 91-628-4884-4
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