Raman spectroscopy for detection of stretched DNAs on superhydrophobic surfaces

Abstract
A novel approach for the study of low concentrated DNAs (60 pM) using microRaman spectroscopy is reported. A superhydrophobic substrate with array of microPillars is fabricated over which the sample was drop casted. The substrate concentrates the molecules in a very small area with higher molecular density, enabling to carry out the microRaman measurements. Two different DNAs (single strand and double strand) were used to investigate through Raman technique. A spectral Raman difference was found to distinguish the ssDNA and dsDNAs. The approach can be of interest for a wide variety of applications ranging from biological materials interactions characterization to the biomedical field. © 2014 Elsevier B.V. All rights reserved.

Citation
Marini, M., Das, G., La Rocca, R., Gentile, F., Limongi, T., Santoriello, S., … Di Fabrizio, E. (2014). Raman spectroscopy for detection of stretched DNAs on superhydrophobic surfaces. Microelectronic Engineering, 119, 151–154. doi:10.1016/j.mee.2014.04.008

Publisher
Elsevier BV

Journal
Microelectronic Engineering

DOI
10.1016/j.mee.2014.04.008

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