Helicobacter pylori (H. pylori) antibiotic resistance is the main factor affecting the efficacy of the current eradicating therapies. The aim of this editorial is to report on the recent information about the mechanisms accounting for the resistance to the different antibiotics currently utilized in H. pylori eradicating treatments. Different mechanisms of resistance to clarithromycin, metronidazole, quinolones, amoxicillin and tetracycline are accurately detailed (point mutations, redox intracellular potential, pump efflux systems, membrane permeability) on the basis of the most recent data available from the literature. The next hope for the future is that by improving the knowledge of resistance mechanisms, the elaboration of rational and efficacious associations for the treatment of the infection will be possible. Another auspicious progress might be the possibility of a cheap, feasible and reliable laboratory test to predict the outcome of a therapeutic scheme.

Francesco, V., Zullo, A., Hassan, C., Giorgio, F., Rosania, R., Ierardi, E., Mechanisms of Helicobacter pylori antibiotic resistance: An updated appraisal, <<WORLD JOURNAL OF GASTROINTESTINAL PATHOPHYSIOLOGY>>, N/A; 2 (3): 35-41. [doi:10.4291/wjgp.v2.i3.35] [http://hdl.handle.net/10807/35106]

Mechanisms of Helicobacter pylori antibiotic resistance: An updated appraisal

Hassan, Cesare;
2011

Abstract

Helicobacter pylori (H. pylori) antibiotic resistance is the main factor affecting the efficacy of the current eradicating therapies. The aim of this editorial is to report on the recent information about the mechanisms accounting for the resistance to the different antibiotics currently utilized in H. pylori eradicating treatments. Different mechanisms of resistance to clarithromycin, metronidazole, quinolones, amoxicillin and tetracycline are accurately detailed (point mutations, redox intracellular potential, pump efflux systems, membrane permeability) on the basis of the most recent data available from the literature. The next hope for the future is that by improving the knowledge of resistance mechanisms, the elaboration of rational and efficacious associations for the treatment of the infection will be possible. Another auspicious progress might be the possibility of a cheap, feasible and reliable laboratory test to predict the outcome of a therapeutic scheme.
2011
Inglese
Francesco, V., Zullo, A., Hassan, C., Giorgio, F., Rosania, R., Ierardi, E., Mechanisms of Helicobacter pylori antibiotic resistance: An updated appraisal, <<WORLD JOURNAL OF GASTROINTESTINAL PATHOPHYSIOLOGY>>, N/A; 2 (3): 35-41. [doi:10.4291/wjgp.v2.i3.35] [http://hdl.handle.net/10807/35106]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/35106
Citazioni
  • ???jsp.display-item.citation.pmc??? 49
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact