Telomere shortening in peripheral blood mononuclear cells (PBMCs) has been associated with biological age and several chronic degenerative diseases. However, the relationship between telomere length and sarcopenia, a hallmark of the aging process, is unknown. The aim of the present study was therefore to determine whether PBMC telomeres obtained from sarcopenic older persons were shorter relative to non-sarcopenic peers. We further explored if PBMC telomere length was associated with frailty, a major clinical correlate of sarcopenia.
Marzetti, E., Lorenzi, M., Antocicco, M., Bonassi, S., Celi, M., Mastropaolo, S., Settanni, S., Valdiglesias, V., Landi, F., Bernabei, R., Onder, G., Shorter telomeres in peripheral blood mononuclear cells from older persons with sarcopenia: results from an exploratory study, <<FRONTIERS IN AGING NEUROSCIENCE>>, 2014; 2014/6 (233): 233-233. [doi:10.3389/fnagi.2014.00233] [http://hdl.handle.net/10807/76988]
Shorter telomeres in peripheral blood mononuclear cells from older persons with sarcopenia: results from an exploratory study
Marzetti, EmanuelePrimo
;Lorenzi, MariaSecondo
;Antocicco, Manuela;Celi, Michela;Mastropaolo, Simona;Settanni, Silvana;Landi, Francesco;Bernabei, RobertoPenultimo
;Onder, GrazianoUltimo
2014
Abstract
Telomere shortening in peripheral blood mononuclear cells (PBMCs) has been associated with biological age and several chronic degenerative diseases. However, the relationship between telomere length and sarcopenia, a hallmark of the aging process, is unknown. The aim of the present study was therefore to determine whether PBMC telomeres obtained from sarcopenic older persons were shorter relative to non-sarcopenic peers. We further explored if PBMC telomere length was associated with frailty, a major clinical correlate of sarcopenia.
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