Improving the diagnostic workup of deep vein thrombosis: Findings from the Ri-Schedule study
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- Institutt for klinisk medisin [10728]
Abstract
In the Rivaroxaban for Scheduled Workup of Deep Vein Thrombosis (the Ri-Schedule) study, we identified patients with suspected deep vein thrombosis (DVT) of the leg in whom diagnostic workup could be deferred while receiving empiric anticoagulation therapy with rivaroxaban. Our findings provide an alternative for anticoagulation therapy than the standard empiric treatment with low-molecular-weight heparin. They may also aid physicians in deciding in which patients diagnostic workup may safely be deferred. Furthermore, we found that a diagnostic management strategy incorporating negative stand-alone D-dimer and a single, whole-leg CUS could safely rule out DVT. The strategy may facilitate an easier and more streamlined diagnostic workup.List of papers
Paper I. Fronas SG, Wik HS, Dahm AEA, Jorgensen CT, Gleditsch J, Raouf N, et al. Safety of D-dimer testing as a stand-alone test for the exclusion of deep vein thrombosis as compared with other strategies. J Thromb Haemost. 2018;16(12):2471-81. DOI: 10.1111/jth.14314. The article is included in the thesis. Also available at: https://doi.org/10.1111/jth.14314 |
Paper II. Fronas SG, Dahm AEA, Wik HS, Jørgensen CT, Gleditsch J, Raouf N, et al. Safety and feasibility of rivaroxaban in deferred workup of patients with suspected deep vein thrombosis. Blood Adv. 2020;4(11):2468-76. DOI 10.1182/bloodadvances.2020001556. The article is included in the thesis. Also available at: https://doi.org/10.1182/bloodadvances.2020001556 |
Paper III. Fronas SG, Jørgensen CT, Dahm AEA, Wik HS, Gleditsch J, Raouf N, et al. Safety of a strategy combining D-dimer testing and whole-leg ultrasonography to rule out deep vein thrombosis. Blood Adv. 2020;4(20):5002-10. DOI 10.1182/bloodadvances.2020002173. The article is included in the thesis. Also available at: https://doi.org/10.1182/bloodadvances.2020002173 |