Multikinase Networks: Two-Component Signaling Networks Integrating Multiple Stimuli
Francis, VI; Porter, SL
Date: 21 May 2019
Journal
Annual Review of Microbiology
Publisher
Annual Reviews
Publisher DOI
Abstract
Bacteria depend on two-component systems (TCSs) to detect and respond to threats.
Simple pathways comprise a single sensor kinase (SK) that detects a signal and activates a
response regulator (RR) protein to mediate an appropriate output. These simple pathways
with only a single SK are not that well suited to making complex decisions ...
Bacteria depend on two-component systems (TCSs) to detect and respond to threats.
Simple pathways comprise a single sensor kinase (SK) that detects a signal and activates a
response regulator (RR) protein to mediate an appropriate output. These simple pathways
with only a single SK are not that well suited to making complex decisions where multiple
different stimuli need to be evaluated. A recently emerging theme is the existence of
multikinase-networks (MKNs) where multiple SKs collaborate to detect and integrate
numerous different signals to regulate a major lifestyle switch e.g. virulence, sporulation,
biofilm formation and cell division. In this review, the role of MKNs and the phosphosignalling
mechanisms underpinning their signal integration and decision making will be explored.
Biosciences - old structure
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