Please use this identifier to cite or link to this item: http://hdl.handle.net/10884/1323
Title: New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
Authors: Ramalhete, Cátia
Molnar, Joseph
Mulhovo, Silva
Rosário, Virgilio Estólio
Ferreira, Maria José
Issue Date: Oct-2009
Publisher: Bioorganic & Medicinal Chemistry
Abstract: The novel cucurbitacins, balsaminagenin A and B (1-2) and balsaminoside A (3) and the know cucurbitacin karavelagenin C (4), together with five new mono or diacylated derivatives (5-9) of karavelagenin C were evaluated for multidrug resistance reversing activity on human MDR1 gene transfected mouse lymphoma cells. Compounds 2-6 exhibited a strong activity compared with that of the positive control, verapamil. Structure-activity relationships are discussed. Moreover, in the checkerboard model of combination chemotherapy, the interaction between doxorubicin and compounds 2-5 synergistically enhanced the effect of the anticancer drug. Compounds 1-4 were isolated from the aerial parts of Momordica balsamina L. The structures of the compounds were established on the basis of spectroscopic methods including 2D NMR experiments (COSY, HMQC, HMBC and NOESY).
URI: http://hdl.handle.net/10884/1323
Appears in Collections:A CS/CN - Artigos

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