A novel 3D modelling and simulation technique in thermotherapy predictive analysis on biological tissue
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URI: http://hdl.handle.net/10902/4235DOI: 10.1117/12.728411
ISBN: 978-0-8194-6776-8
ISSN: 1996-756X
ISSN: 0277-786X
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2007Derechos
© 2007 Society of Photo-Optical Instrumentation Engineers and Optical Society of America. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Publicado en
F. Fanjul-Vélez, J. L. Arce-Diego, O. G. Romanov, and A. L. Tolstik, "A novel 3D modelling and simulation technique in thermotherapy predictive analysis on biological tissue," in European Conference on Biomedical Optics: Therapeutic Laser Applications and Laser-Tissue Interactions III, A. Vogel, ed., Vol. 6632 of Proceedings of SPIE-OSA Biomedical Optics, 66320D, (2007)
Editorial
SPIE Society of Photo-Optical Instrumentation Engineers-
Optical Society of America
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Palabras clave
Optical treatment
Thermotherapy
Bio-heat equation
Finite difference numerical method
Thermal damage
Resumen/Abstract
Optical techniques applied to biological tissue allow the development of new tools in medical praxis, either in tissue characterization or treatment. Examples of the latter are Photodynamic Therapy (PDT) or Low Intensity Laser Treatment (LILT), and also a promising technique called thermotherapy, that tries to control temperature increase in a pathological tissue in order to reduce or even eliminate pathological effects. The application of thermotherapy requires a previous analysis in order to avoid collateral damage to the patient, and also to choose the appropriate optical source parameters. Among different implementations of opto-thermal models, the one we use consists of a three dimensional Beer-Lambert
law for the optical part, and a bio-heat equation, that models heat transference, conduction, convection, radiation, blood perfusion and vaporization, solved via a numerical spatial-temporal explicit finite difference approach, for the thermal part. The usual drawback of the numerical method of the thermal model is that convergence constraints make spatial and temporal steps very small, with the natural consequence of slow processing. In this work, a new algorithm implementation is used for the bio-heat equation solution, in such a way that the simulation time decreases considerably. Thermal damage based on the Arrhenius integral damage is also considered.
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