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Article (Scientific journals)
Cadherin-11 is highly expressed in rhabdomyosarcomas and during differentiation of myoblasts in vitro.
Markus, M. A.; Reichmuth, C.; Atkinson, M. J. et al.
1999In Journal of Pathology, 187 (2), p. 164-72
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Keywords :
Animals; Blotting, Northern; Blotting, Western; Cadherins/metabolism; Cell Culture Techniques; Cell Differentiation/physiology; Child; Fluorescent Antibody Technique; Humans; Mice; Mice, Inbred CBA; Muscle, Skeletal/cytology/metabolism; Neoplasm Proteins/metabolism; Rhabdomyosarcoma/metabolism; Tumor Cells, Cultured
Abstract :
[en] Rhabdomyosarcomas bear a morphological and genetic resemblance to developing skeletal muscle. Apart from myogenic marker genes (bHLH factors, myosin, actin), cell adhesion molecules such as N-cadherin and N-CAM have been reported to be expressed both in rhabdomyosarcomas and during myogenesis. The present study demonstrates the expression of another cadherin, cadherin-11, in rhabdomyosarcomas and during differentiation of myoblasts in vitro: cadherin-11, a predominantly mesenchymal cell adhesion molecule, is highly expressed in embryonal rhabdomyosarcomas and alveolar rhabdomyosarcomas, which do not bear the Pax-3-FKHR fusion previously described. Cadherin-11 is down-regulated in normal skeletal muscle and after myotube formation in vitro. The results of this study suggest that cadherin-11 might be involved in myogenesis and that rhabdomyosarcomas may re-express or fail to down-regulate cadherin-11. Since alveolar rhabdomyosarcomas bearing the t(2;13) translocation do not express cadherin-11, it is postulated that Pax-3 and cadherin-11 might be linked and involved in the same myogenic pathway.
Disciplines :
Genetics & genetic processes
Author, co-author :
Markus, M. A.
Reichmuth, C.
Atkinson, M. J.
Reich, U.
Hoffmann, I.
Balling, Rudi 
Anderer, U.
Hofler, H.
Language :
English
Title :
Cadherin-11 is highly expressed in rhabdomyosarcomas and during differentiation of myoblasts in vitro.
Publication date :
1999
Journal title :
Journal of Pathology
ISSN :
0022-3417
Volume :
187
Issue :
2
Pages :
164-72
Peer reviewed :
Peer reviewed
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