Article (Scientific journals)
Cardiac modulation of startle is altered in depersonalization-/derealization disorder: evidence for impaired brainstem representation of baro-afferent neural traffic
Schulz, André; Matthey, J. H.; Vögele, Claus et al.
2016In Psychiatry Research, 240 (1), p. 4-10
Peer reviewed
 

Files


Full Text
Schulz et al. (2016).pdf
Publisher postprint (330.75 kB)
Request a copy

All documents in ORBilu are protected by a user license.

Send to



Details



Abstract :
[en] Patients with depersonalization-/derealization disorder (DPD) show altered heartbeat-evoked brain potentials, which are considered psychophysiological indicators of cortical representation of visceral-afferent neural signals. The aim of the current investigation was to clarify whether the impaired CNS representation of visceral-afferent neural signals in DPD is restricted to the cortical level or is also present in sub-cortical structures. We used cardiac modulation of startle (CMS) to assess baro-afferent signal transmission at brainstem level in 22 DPD and 23 healthy control individuals. The CMS paradigm involved acoustic startle stimuli (105 dB(A), 50 ms) elicited 0, 100, 200, 300, 400 and 500 ms after a cardiac R-wave. In healthy control individuals, we observed lower startle responses at 100 and 300 ms than at 0 and 400 ms after an R-wave. In DPD patients, no effect of the cardiac cycle on startle response magnitude was found. We conclude that the representation of visceral-afferent neural signals at brainstem level may be deficient in DPD. This effect may be due to increased peripheral sympathetic tone or to dysregulated signal processing at brainstem level.
Disciplines :
Neurosciences & behavior
Author, co-author :
Schulz, André  ;  University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE)
Matthey, J. H.
Vögele, Claus ;  University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE)
Schaan, Violetta ;  University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE)
Schächinger, H.
Adler, J.
Beutel, M.
Michal, M.
External co-authors :
yes
Language :
English
Title :
Cardiac modulation of startle is altered in depersonalization-/derealization disorder: evidence for impaired brainstem representation of baro-afferent neural traffic
Publication date :
30 June 2016
Journal title :
Psychiatry Research
ISSN :
0165-1781
Publisher :
Elsevier North Holland Biomedical Press, Limerick, Ireland
Volume :
240
Issue :
1
Pages :
4-10
Peer reviewed :
Peer reviewed
Available on ORBilu :
since 01 April 2016

Statistics


Number of views
131 (3 by Unilu)
Number of downloads
3 (2 by Unilu)

Scopus citations®
 
21
Scopus citations®
without self-citations
13
OpenCitations
 
19
WoS citations
 
21

Bibliography


Similar publications



Contact ORBilu