Abstract :
[en] Inflammasomes are protein complexes that form in response to pathogen-derived or host-derived stress signals. Their activation leads to the production of inflammatory cytokines and promotes a pyrogenic cell death process. The massive release of inflammatory mediators that follows inflammasome activation is a key event in alarming innate immune cells. Growing evidence also highlights the role of inflammasome-dependent cytokines in shaping the adaptive immune response, as exemplified by the capacity of IL-1β to support Th17 responses, or by the finding that IL-18 evokes antigen-independent IFN-γ secretion by memory CD8+ T cells. A deeper understanding of these mechanisms and on how to manipulate this powerful inflammatory system therefore represents an important step forward in the development of improved vaccine strategies. © 2013 Elsevier Ltd.
Dostert, Catherine ;
University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit Ludigs, Kristina; Department of Biochemistry, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Guarda, Greta; Department of Biochemistry, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
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