Article (Scientific journals)
Cardiovascular effects of Org 9487 under isoflurane anaesthesia in man
Osmer, Christian; Wulf, Kay; Vögele, Claus et al.
1998In European Journal of Anaesthesiology, (15), p. 585-589
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Keywords :
Neuromuscular relaxant; Org 9487; Cardiovascular effects
Abstract :
[en] The cardiovascular effects of Org 9487 during isoflurane anaesthesia have been evaluated using three doses around its ED90 for neuromuscular blockade, i.e. 1 mg kg-1, 2 mg kg-1 and 3 mg kg-1. Heart rate increased to 110%, 115% and 118% in patients receiving 1 mg kg-1, 2 mg kg-1 and 3 mg kg-1 respectively. There were no significant effects on systolic and diastolic blood pressures for the two lower dose groups. Patients receiving Org 9487 3 mg kg-1 displayed significant decreases in systolic and diastolic blood pressures (91% and 82% of the control values respectively). Except for heart rate in the group receiving 3 mg kg-1, all measurements returned to baseline after a maximum of 15 min. Six patients experienced a transient increase in airway pressure after administration of Org 9487, which was accompanied by a decrease in oxygen saturation in two out of six subjects, but there was no audible wheezing. These episodes were self-limiting and required no treatment. There were no other adverse reactions to this drug during this study.
Disciplines :
Theoretical & cognitive psychology
Psychiatry
Treatment & clinical psychology
Animal psychology, ethology & psychobiology
Neurosciences & behavior
Identifiers :
UNILU:UL-ARTICLE-2012-806
Author, co-author :
Osmer, Christian
Wulf, Kay
Vögele, Claus ;  University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE)
Zickmann, Bernfried
Hempelmann, Gunther
Language :
English
Title :
Cardiovascular effects of Org 9487 under isoflurane anaesthesia in man
Publication date :
1998
Journal title :
European Journal of Anaesthesiology
ISSN :
1365-2346
Publisher :
Cambridge University Press, Cambridge, United Kingdom
Issue :
15
Pages :
585-589
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 08 August 2013

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