Quality control of no-carrier-added (YCl3)-Y-90 by estimating the labeling efficiency using its reaction with DOTATOC

0358999 - ÚJF 2011 RIV NL eng J - Článek v odborném periodiku
Eigner-Henke, Kateřina - Beran, Miloš - Šrank, Jiří - Melichar, František
Quality control of no-carrier-added (YCl3)-Y-90 by estimating the labeling efficiency using its reaction with DOTATOC.
[Kontrola kvality nenosičově přidaného (YCl3)-Y-90 určením efektivity značení pomocí jeho reakce s DOTATOC.]
Journal of Radioanalytical and Nuclear Chemistry. Roč. 278, č. 1 (2008), s. 25-29. ISSN 0236-5731. E-ISSN 1588-2780
Grant CEP: GA MPO FT-TA2/081
Výzkumný záměr: CEZ:AV0Z10480505
Klíčová slova: TERNARY COMPLEX-FORMATION * NEUROENDOCRINE TUMORS * SOMATOSTATIN ANALOGS
Kód oboru RIV: FR - Farmakologie a lékárnická chemie
Impakt faktor: 0.659, rok: 2008

The (YCl3)-Y-90 radionuclide precursor (solution of Y-90(3+) in diluted HCl) of high purity and high specific activity is already commercially produced and successfully used in nuclear medicine. At the Nuclear Physics Institute ASCR, the (YCl3)-Y-90 radionuclide precursor is prepared using extraction (SrY)-Sr-90-Y-90 generator (technology of centrifuge extractors with di-2-ethylhexylphosphoric acid, D2EHPA).(1) Its radionuclidic, radiochemical, and chemical purity were examined and specified. The procedure developed for labeling of DOTA-Tyr(3)-octreotide (DOTATOC) with carrier-free Y-86/90 by ROSCH2 at the Institute of Nuclear Chemistry of the University Mainz was optimized and modified in our Department of Radiopharmaceuticals at NPI ASCR as standard labeling test (SLT) for analytical purposes. The SLT as a method for (YCl3)-Y-90 radionuclide precursor quality control determining its labeling efficiency using ITLC SG chromatography is described and proposed thereinafter.

Testovány analýzy radiofarmak pomocí radionuklidového prekurzoru (YCl3)-Y-90. Dosažena efektivita značení větší než 95%.
Trvalý link: http://hdl.handle.net/11104/0006417