Modulation of adenylyl cyclase activity by baclofen in the developing rat brain: difference between cortex, thalamus and hippocampus

0142351 - FGU-C 20020077 RIV IE eng J - Článek v odborném periodiku
Hejnová, Lucie - Ihnatovych, Ivanna - Novotný, Jiří - Kubová, Hana - Mareš, Pavel - Svoboda, Petr
Modulation of adenylyl cyclase activity by baclofen in the developing rat brain: difference between cortex, thalamus and hippocampus.
Neuroscience Letters. Roč. 330, č. 1 (2002), s. 9-12. ISSN 0304-3940. E-ISSN 1872-7972
Grant CEP: GA ČR GA309/99/0207; GA ČR GA309/01/0255
Výzkumný záměr: CEZ:AV0Z5011922
Klíčová slova: GABA(B) receptors * baclofen * adenylyl cyclase
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 2.100, rok: 2002

Ontogenetic changes in the levels of GABAB receptors and their ability to modulate adenylyl cyclase (AC) activity were analyzed in rat cortex, thalamus and hippocampus. Our data indicate that the inhibitory effect of baclofen on AC in cortex and thalamus is primarily mediated through the alpha subunits of Gi/Go proteins. The stimulatory effect of baclofen in hippocampus may be explained by engagenement of Gbetagamma-subunits.
Trvalý link: http://hdl.handle.net/11104/0040057