Apical ouabain-sensitive and ouabain-insensitive ATPases in rat colonic epithelium

0142376 - FGU-C 20020099 RIV DE eng J - Článek v odborném periodiku
Vagnerová, R. - Zemanová, Zdeňka - Pácha, Jiří - Šmídová, J.
Apical ouabain-sensitive and ouabain-insensitive ATPases in rat colonic epithelium.
Acta histochemica. Roč. 104, č. 4 (2002), s. 407-411. ISSN 0065-1281. E-ISSN 1618-0372
Grant ostatní: GA UK(XC) 43/1999/C
Výzkumný záměr: CEZ:AV0Z5011922
Klíčová slova: H,K-ATPase * colonic enterocytes * colon
Kód oboru RIV: EA - Morfologické obory a cytologie
Impakt faktor: 0.867, rok: 2002

Present study on the distribution patterns of apical ATPases in the colon using catalytic histochemistry demonstrated activity of the ATPases localized both at the apical and basolateral regions of colonocytes. The basolateral activity was almost completely inhibited by ouabain, but apical ATPase activity was only partially inhibited by ouabain. ATPases demonstrated histochemically in the present study were identified immunohistochemically as colonic (-subunit H,K-ATPAse (in the apical cell membrane of colonocytes along the entire length of crypts) and as (1-subunit Na,K-ATPase (in the basolteral membrane).
Trvalý link: http://hdl.handle.net/11104/0040082