Polymer hydrogels usable for nervous tissue repair

0173567 - UEM-P 20023008 RIV NL eng J - Článek v odborném periodiku
Lesný, Petr - DeCroos, Jane - Přádný, Martin - Vacík, Jiří - Michálek, Jiří - Woerly, S. - Syková, Eva
Polymer hydrogels usable for nervous tissue repair.
Journal of Chemical Neuroanatomy. Roč. 23, - (2002), s. 243-247. ISSN 0891-0618. E-ISSN 1873-6300
Grant CEP: GA MŠMT LN00A065; GA ČR GV307/96/K226
Výzkumný záměr: CEZ:AV0Z5039906
Klíčová slova: Extracellular space * Astrocytes
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 2.696, rok: 2002

Macroporous hydrogels based on crosslinked poly hydroxyethyl-methacrylate (pHEMA) and poly N-(2-hydroxypropyl)-methacrylamide (pHPMA) were implanted into the rat cortex and the cellular invasion into the hydrogel was evaluated by means of immunohistochemical methods and tetramethylammonium diffusion measurements. Astrocytes and NF160-positive axons were found in both types of the hydrogels; however there was a massive ingrowth of connective tissue elements into the pHPMA hydrogel. These changes were accompanied by corresponding changes in the extracellular space volume fraction and tortuosity of the hydrogels.
Trvalý link: http://hdl.handle.net/11104/0070598