An ATP-Dependent Step Is Required for the Translocation of Microinjected Precursor mRNA into Nuclear Speckles

0173585 - UEM-P 20023030 RIV CZ eng J - Článek v odborném periodiku
Kopský, Vojtěch - Večeřová, Jaromíra - Melčák, Ivo - Pliss, Artem - Štulík, J. - Koberna, Karel - Tomášková, L. - Raška, Ivan
An ATP-Dependent Step Is Required for the Translocation of Microinjected Precursor mRNA into Nuclear Speckles.
Folia Biologica. Roč. 48, - (2002), s. 69-72. ISSN 0015-5500. E-ISSN 0015-5500
Grant CEP: GA ČR GA304/00/1481; GA ČR GA304/01/0729; GA AV ČR IAA5039103
Výzkumný záměr: CEZ:AV0Z5039906; CEZ:MSM 111100003
Klíčová slova: ATP-dependent step * HeLa cell nucleus
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 0.615, rok: 2002

Nuclear speckles (speckles) represent a dictinct nuclear compartment within the interchromatin space and are enriched in splicing factors. It has been suggested that the targeting of RNA into speckles consists of two interdependent steps, namely the diffusion process, folowed by the energy-dependent translocation of RNA into the speckles. In the present study, we confirm the existence of these two steps and show that this latter translocation is ATP dependent.
Trvalý link: http://hdl.handle.net/11104/0070616