Počet záznamů: 1  

Exogenous administration of gangliosides inhibits FcepsilonRI-mediated mast cell degranulation by decreasing the activity of phospholipase Cgamma

  1. 1.
    0191605 - UMG-J 20033110 RIV US eng J - Článek v odborném periodiku
    Dráberová, Lubica - Dudková, L. - Boubelík, Michael - Tolarová, Helena - Šmíd, F. - Dráber, Petr
    Exogenous administration of gangliosides inhibits FcepsilonRI-mediated mast cell degranulation by decreasing the activity of phospholipase Cgamma.
    Journal of Immunology. Roč. 171, č. 7 (2003), s. 3585-3593. ISSN 0022-1767. E-ISSN 1550-6606
    Grant CEP: GA MŠMT LN00A026; GA ČR GA204/00/0204; GA ČR GA204/03/0594; GA ČR GA310/00/0205; GA ČR GA301/03/0596; GA AV ČR IAA5052005; GA AV ČR IAA7052006; GA AV ČR IAA5052310; GA MZd NB6758
    Výzkumný záměr: CEZ:AV0Z5052915
    Klíčová slova: mast cell * plasma membrane * IgE
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 6.702, rok: 2003

    In this study we analyzed the molecular mechanisms of an inhibition of mast cell activity by gangliosides. Rat basophilic leukemia cells pretreated with isolated brain gangliosides exhibited decreased secretory response and calcium release. Although the production of phosphoinositides was also decreased, activity of phosphatidylinositol 3-kinase was not affected. Gangliosides had no effect on association of aggregated FcepsilonRI with lipid rafts and on tyrosine phosphorylation of the receptor, Syk kinase and LAT adaptor. However, they inhibited enzymatic activity of phospholipase Cgamma. This resulted in decreased production of inositol 1,4,5-trisphosphate and an inhibition of calcium response. The combined data suggest that gangliosides inhibit formation of plasma membrane-associated signaling assemblies containing phospholipase Cgamma but not early activation events.
    Trvalý link: http://hdl.handle.net/11104/0087345

     
     

Počet záznamů: 1  

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