Combining combinatorial chemistry and affinity chromatography for systematically probing protein-ligand interactions: application to the development of highly selective inhibitors of human betaine: homocysteine .I.S./I.-methyltransferase

0194859 - UOCHB-X 20030167 RIV IT eng C - Konferenční příspěvek (zahraniční konf.)
Collinsová, Michaela - Castro, C. - Garrow, T. A. - Yiotakis, A. - Dive, V. - Jiráček, Jiří
Combining combinatorial chemistry and affinity chromatography for systematically probing protein-ligand interactions: application to the development of highly selective inhibitors of human betaine: homocysteine .I.S./I.-methyltransferase.
Peptides 2002. Proceedings of the Twenty-Seventh European Peptide Symposium. Napoli: Edizioni Ziino, 2002 - (Benedetti, E.; Pedone, C.), s. 942-943. ISBN 88-900948-1-8.
[Peptides 2002. European Peptide Symposium /27./. Sorrento (IT), 31.08.2002-06.09.2002]
Grant CEP: GA AV ČR IAB4055003
Výzkumný záměr: CEZ:AV0Z4055905
Klíčová slova: BHMT * inhibitor * affinity chromatography
Kód oboru RIV: CE - Biochemie

The results reported in this study validate the concept that combining combinatorial chemistry to affinity chromatography makes possible to identify, without any .I.a priori./I. hypothesis, novel protein targets for phosphinic pseudopeptides. And .I.vice versa./I., selective inhibitors of BHMT were developed despite rather limited diversity of pseudopeptide library used to fish out the proteins.
Trvalý link: http://hdl.handle.net/11104/0090529