An efficient way to helically chiral pyridines

0328022 - ÚOCHB 2010 PL eng A - Abstrakt
Jančařík, Andrej - Stará, Irena G. - Starý, Ivo
An efficient way to helically chiral pyridines.
22nd Conference on Advances in Organic Synthesis. Warsaw: Institut of organic Chemistry of the polish Academy of Sciences, 2009. P13.
[Conference on Advances in Organic Synthesis /22./. 08.07.2009-12.07.2009, Karpacz]
Grant CEP: GA ČR GA203/07/1664; GA AV ČR IAA400550916; GA MŠMT LC512
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: azahelicenes * chiral pyridines * asymmetric synthesis
Kód oboru RIV: CC - Organická chemie

Aza[5]helicene-like molecules are easily accessible from the commercially available bromopyridine. The key step of the whole reaction sequence is the thermodynamically controlled microwave-mediated cycloisomerization of triynes catalyzed by Co--complex, which provides virtually a single diastereoizomer.
Trvalý link: http://hdl.handle.net/11104/0174432