Alterations in synaptic curvature in the dentate gyrus following induction of long-term potentiation, long-term depression, and treatment with the N-methyl-D-aspartate receptor antagonist CPP

0354978 - ÚEM 2011 RIV GB eng J - Článek v odborném periodiku
Medvedev, N. I. - Popov, V. I. - Dallerac, G. - Davies, H.A. - Laroche, S. - Kraev, I. V. - Rodríguez Arellano, Jose Julio - Doyere, V. - Stewart, M.G.
Alterations in synaptic curvature in the dentate gyrus following induction of long-term potentiation, long-term depression, and treatment with the N-methyl-D-aspartate receptor antagonist CPP.
Neuroscience. Roč. 171, č. 2 (2010), s. 390-397. ISSN 0306-4522. E-ISSN 1873-7544
Výzkumný záměr: CEZ:AV0Z50390703
Klíčová slova: D synaptic ultrastructure * hippocampus * long term potentiation and depression
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 3.215, rok: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0354978_01.pdf

Alterations in curvature of the post synaptic density (PSD) and apposition zone (AZ), are believed to play an important role in determining synaptic efficacy. In the present study we have examined curvature of PSDs and AZs 24 h following homosynaptic long-term potentiation (LTP), and heterosynaptic long-term depression (LTD) in vivo, in awake adult rats.Very large and significant changes in 3-D measurements of AZ and PSD curvature occurred 24 h following both LTP and LTD, with a flattening of the normal concavity of mushroom spine heads and a change to convexity for thin spines.
Trvalý link: http://hdl.handle.net/11104/0193854