Ileal Peyer's Patches Are Not Necessary for Systemic B Cell Development and Maintenance and Do Not Contribute Significantly to the Overall B Cell Pool in Swine

0370664 - MBÚ 2012 RIV US eng J - Článek v odborném periodiku
Šinkora, Marek - Štěpánová, Kateřina - Butler, J. - Francis, D. - Santiago-Mateo, K. - Potočková, Hana - Kárová, Kristýna - Šinkorová, Jana
Ileal Peyer's Patches Are Not Necessary for Systemic B Cell Development and Maintenance and Do Not Contribute Significantly to the Overall B Cell Pool in Swine.
Journal of Immunology. Roč. 187, č. 10 (2011), s. 5150-5161. ISSN 0022-1767. E-ISSN 1550-6606
Grant CEP: GA MŠMT ME09089; GA ČR GAP502/10/0038
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: ANTIBODY REPERTOIRE DEVELOPMENT * LYMPHOID-TISSUES * NEONATAL PIGLETS
Kód oboru RIV: EC - Imunologie
Impakt faktor: 5.788, rok: 2011

Based on studies of sheep, the ileal Peyer’s patches (IPP) have been regard as a type of primary lymphoid tissue similar to the bursa of Fabricius in chicken. Since bursectomy results in B cell deficiency, we wondered if resection of the IPP of piglets would have a similar effect. Comparison of IPP resected, surgical shams and untreated germ-free piglets, all of which were later colonized with a defined commensal flora demonstrates that resection of the IPP did not alter the level and phenotype of B and T cells in lymphoid tissues and the blood during 10 weeks after surgery
Trvalý link: http://hdl.handle.net/11104/0204392