Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer

0372311 - ÚMG 2012 RIV GB eng J - Článek v odborném periodiku
Medema, R.H. - Macůrek, Libor
Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer.
F1000 biology reports. Roč. 3, - (2011), e10. ISSN 1757-594X
Grant CEP: GA ČR GAP301/10/1525; GA ČR GPP305/10/P420
Výzkumný záměr: CEZ:AV0Z50520514
Klíčová slova: checkpoint * DNA damage * cancer
Kód oboru RIV: EB - Genetika a molekulární biologie

Dysregulation of the cell cycle is the underlying mechanism of neoplasia. Healthy cells prevent propagation of DNA mutations to progeny by activation of cellular checkpoints, which allows time for DNA repair. On the other hand, activation of the DNA damage response is also the general principle of many current cancer treatments. Thus, recent advances in understanding how checkpoints in the cell cycle work at the molecular level open the door to new approaches to antitumor therapy.
Trvalý link: http://hdl.handle.net/11104/0205659