Gradient Method Optimization of Penicillin Production

0377345 - ÚTIA 2013 RIV CN eng C - Konferenční příspěvek (zahraniční konf.)
Pčolka, M. - Čelikovský, Sergej
Gradient Method Optimization of Penicillin Production.
Proceedings of the 24th Chinese Control and Decision (2012 CCDC). Vol. IEEE Catalog Number: CFP1251D-CDR. Taiyuan: IEEE, 2012, s. 74-79. ISBN 978-1-4577-2072-7.
[The 24th Chinese Control and Decision Conference (2012 CCDC). Taiyuan (CN), 23.05.2012-25.05.2012]
Grant CEP: GA ČR(CZ) GAP103/12/1794
Institucionální podpora: RVO:67985556
Klíčová slova: fermentation process * penicillin * gradient method * optimization
Kód oboru RIV: BC - Teorie a systémy řízení
www.ccdc.neu.edu.cn

A fermentation process is generally defined as a biological process containing the growth of the biomass (bacteria, yeasts) resulting from the consumption of essential substrate supplies (source of carbon, nitrogen, oxygen, etc.). The biomass growth is usually followed by the production of various products from which especially the variety of antibiotics makes the fermentation processes attractive for the industrial utilization. However, the complicated dynamics, high level of uncertainty and nonlinearity and difficult online measurement of the process variables come hand in hand with the attractivity and turn the attempts on optimal control of the fermentation process into a very delicate challenge. To tackle it, the theory of the gradient projection method has been partially adapted and fully implemented by the authors of this paper. Numerical experiments show its significantly better performance than for other known methods. Moreover, these experiments reveal an interesting ”superprofile” visible for long cultivation times.
Trvalý link: http://hdl.handle.net/11104/0209522