Metabolic Effects of n-3 PUFA as Phospholipids Are Superior to Triglycerides in Mice Fed a High-Fat Diet: Possible Role of Endocannabinoids

0377920 - FGÚ 2013 RIV US eng J - Článek v odborném periodiku
Rossmeisl, Martin - Macek Jílková, Zuzana - Kuda, Ondřej - Jeleník, Tomáš - Medříková, Daša - Staňková, B. - Kristinsson, B. - Haraldsson, G.G. - Svensen, H. - Stoknes, I. - Sjövall, P. - Magnusson, Y. - Balvers, M.G.J. - Verhoeckx, K.C.M. - Tvrzická, E. - Bryhn, M. - Kopecký, Jan
Metabolic Effects of n-3 PUFA as Phospholipids Are Superior to Triglycerides in Mice Fed a High-Fat Diet: Possible Role of Endocannabinoids.
PLoS ONE. Roč. 7, č. 6 (2012), e38834. ISSN 1932-6203. E-ISSN 1932-6203
Grant CEP: GA MZd(CZ) NS10528; GA ČR(CZ) GAP301/10/1420
Výzkumný záměr: CEZ:AV0Z50110509
Institucionální podpora: RVO:67985823
Klíčová slova: n-3 PUFA * marine phospholipids * obesity * insulin resistance
Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
Impakt faktor: 3.730, rok: 2012

n-3 polyunsaturated fatty acids, namely docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), reduce the risk of cardiovascular disease and can ameliorate many of obesity- associated disorders. Compared with triglycerides, dietary DHA/EPA administered as phospholipids are superior in preserving a healthy metabolic profile under obesogenic conditions, possibly reflecting better bioavalability and improved modulation of the endocannabinoid system activity in WAT of mice
Trvalý link: http://hdl.handle.net/11104/0209941