Počet záznamů: 1
Polydendrocytes Display Large Lineage Plasticity following Focal Cerebral Ischemia
- 1.0379159 - ÚEM 2013 RIV US eng J - Článek v odborném periodiku
Honsa, Pavel - Pivoňková, Helena - Džamba, Dávid - Filipová, Marcela - Anděrová, Miroslava
Polydendrocytes Display Large Lineage Plasticity following Focal Cerebral Ischemia.
PLoS ONE. Roč. 7, č. 5 (2012), e36816. ISSN 1932-6203. E-ISSN 1932-6203
Grant CEP: GA ČR GA305/09/0717; GA ČR(CZ) GAP303/12/0855
Grant ostatní: GA MŠk(CZ) GA UK383711; GA ČR(CZ) GD309/08/H079
Výzkumný záměr: CEZ:AV0Z50390703
Institucionální podpora: RVO:68378041
Klíčová slova: NG2 glia * CNS regeneration * patch clamp
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 3.730, rok: 2012
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0036816
Here we show that polydendrocytes participate in CNS repair following focal cerebral ischemia. We followed their fate after a permanent middle cerebral artery occlusion (MCAo) in adult NG2creBAC:ZEG double transgenic mice, in which enhanced green fluorescent protein (EGFP) is expressed in polydendrocytes and their progeny. We found that 3 days after MCAo the EGFP(+) cells markedly proliferate,. however, in later phases after MCAo they give rise to a subpopulation of reactive astrocytes and moreover, some EGFP(+) cells expressed doublecortin and displayed membrane properties typical for neural precursor cells, Taken together, our data indicate that polydendrocytes in the dorsal cortex display multipotent differentiation potential after focal ischemia.
Trvalý link: http://hdl.handle.net/11104/0210421
Počet záznamů: 1