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Biological effects of selenium compounds with a particular attention to the ontogenetic development

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    0380489 - FGÚ 2013 RIV CZ eng J - Článek v odborném periodiku
    Ošťádalová, Ivana
    Biological effects of selenium compounds with a particular attention to the ontogenetic development.
    Physiological Research. Roč. 61, Suppl.1 (2012), S19-S34. ISSN 0862-8408. E-ISSN 1802-9973
    Grant CEP: GA MŠk(CZ) 1M0510
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: development * selenium toxicity * cataractogenic effect * lethal effect * cardioprotective effect
    Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
    Impakt faktor: 1.531, rok: 2012

    Toxicity of selenium (Se) depends besides the chemical form, state of organism, interactions with of heavy metals, on the stage of ontogenetic development. Young rats survive the dose of Se, that is lethal in adult rats. However, the same dose of Se induces in young rats the cataract of eye lenses. The incidence of cataract may be suppressed by premature weaning, lower hydration of sucklings, change of water soluble/insoluble lens proteins ratio, thyroxine treatment, and by interaction with mercury. As Se is involved in the maintanence of cell redox state, the cardioprotective effect was observed after ischemia/reperfusion injury
    Trvalý link: http://hdl.handle.net/11104/0211185

     
     
Počet záznamů: 1  

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