Impact of Dietary Gluten on Regulatory T Cells and Th17 Cells in BALB/c Mice

0382232 - MBÚ 2013 RIV US eng J - Článek v odborném periodiku
Antvorskov, J. Ch. - Fundová, Petra - Buschard, K. - Funda, David P.
Impact of Dietary Gluten on Regulatory T Cells and Th17 Cells in BALB/c Mice.
PLoS ONE. Roč. 7, č. 3 (2012), e33315. ISSN 1932-6203. E-ISSN 1932-6203
Grant CEP: GA ČR GA303/06/1329; GA ČR GA310/09/1640; GA MZd(CZ) NS10340
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: INCREASED INTESTINAL PERMEABILITY * INFLAMMATORY-BOWEL-DISEASE * NONOBESE DIABETIC MICE
Kód oboru RIV: EC - Imunologie
Impakt faktor: 3.730, rok: 2012

Dietary gluten influences the development of type 1 diabetes (T1D) and a gluten-free (GF) diet has a protective effect on the development of T1D. Gluten may influence T1D due to its direct effect on intestinal immunity; however, these mechanisms have not been adequately studied. We studied the effect of a GF diet compared to a gluten-containing standard (STD) diet on selected T cell subsets, associated with regulatory functions as well as proinflammatory Th17 cells, in BALB/c mice. Furthermore, we assessed diet-induced changes in the expression of various T cell markers, and determined if changes were confined to intestinal or non-intestinal lymphoid compartments
Trvalý link: http://hdl.handle.net/11104/0212517