Počet záznamů: 1
Single amino acid residue in the M4 domain of GluN1 subunit regulates the surface delivery of NMDA receptors
- 1.0386496 - FGÚ 2013 RIV US eng J - Článek v odborném periodiku
Kaniaková, Martina - Lichnerová, Katarina - Vyklický ml., Ladislav - Horák, Martin
Single amino acid residue in the M4 domain of GluN1 subunit regulates the surface delivery of NMDA receptors.
Journal of Neurochemistry. Roč. 123, č. 3 (2012), s. 385-395. ISSN 0022-3042. E-ISSN 1471-4159
Grant CEP: GA ČR(CZ) GAP303/11/0075; GA ČR(CZ) GBP304/12/G069; GA ČR(CZ) GAP303/12/1464
Výzkumný záměr: CEZ:AV0Z50110509
Institucionální podpora: RVO:67985823
Klíčová slova: assembly * glutamate receptor * ion channel
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 3.973, rok: 2012
Using chimeric and mutated GluN1 subunits expressed in heterologous cells, we identified a single amino acid residue within the fourth membrane domain (M4) of GluN1 subunit, L830, that regulates the surface number of NMDA receptors. Our experiments show that this residue is not critical for the interaction between GluN1 and GluN2 subunits or for the formation of functional receptors, but rather that it regulates the forward trafficking of the NMDA receptors
Trvalý link: http://hdl.handle.net/11104/0220184
Počet záznamů: 1