Počet záznamů: 1
RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation
- 1.0391765 - FGÚ 2014 RIV GB eng J - Článek v odborném periodiku
Tariq, A. - Garncarz, W. - Handl, C. - Balík, Aleš - Pusch, O. - Jantsch, M.F.
RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation.
Nucleic Acids Research. Roč. 41, č. 4 (2013), s. 2581-2593. ISSN 0305-1048. E-ISSN 1362-4962
Institucionální podpora: RVO:67985823
Klíčová slova: RNA * adenosine * ADAR2
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 8.808, rok: 2013
RNA editing by adenosine deaminases that act on RNA (ADARs) diversifies the transcriptome by changing adenosines to inosines. Have isolated three proteins that repress ADAR2-mediated RNA editing. RPS14, SFRS9 and DDX 15 interact with RNA. Overexpression or depletion of these proteins can decrease or increase editing levels by 15 %, thus allowing a modulation of RNA editing up to 30 %. Expression of the three factors decreases during mouse brain development. Moreover, expression levels of SFRS9 and DDX15 respond strongly to neuronal stimulation or repression
Trvalý link: http://hdl.handle.net/11104/0220746
Počet záznamů: 1