Genomics of introgression across a species barrier: Half a Million SNPs across the European house mouse hybrid zone

0392831 - ÚBO 2014 FR eng A - Abstrakt
Baird, Stuart J. E. - Macholán, Miloš - Munclinger, P. - Piálek, Jaroslav
Genomics of introgression across a species barrier: Half a Million SNPs across the European house mouse hybrid zone.
Speciation 2013. Montpellier, 2013.
[European Conference on Speciation Research /2./. 27.05.2013-29.05.2013, Montpellier]
Institucionální podpora: RVO:68081766
Klíčová slova: European House Mouse hybrid zone
Kód oboru RIV: EG - Zoologie
http://kimura.univ-montp2.fr/speciation2013/wp-content/uploads/2013/02/SPECIATION2013_abstract_book.pdf

Understanding speciation as a birth-death process requires study not only of the maintenance of species barriers, but also of those forces acting to break them down ("speciation genes" and "anti-speciation" genes). We use the European House Mouse hybrid zone as a natural experiment to examine such forces. When SNP marker data is dense on the recombination map it cannot be treated as a series of independent loci but can, instead and more naturally, be analysed in terms of Fisher’s representation of the outcome of admixture and recombination: the ancestral source of blocks of DNA along the genome and the position of junctions (arising from recombination) where that source state changes. Cascades in the size of blocks allow ancestral polymorphism to be distinguished from introgression polymorphism. Frequency spectra of introgressed block sizes allow inference of the time since secondary contact. Geographic outlier analysis of blocks allow regions of the genome associated with the introgression of "antispeciation" genes across the species barrier to be identified. These insights increase our understanding not only of the mouse species barrier, but also how it can decay in its natural setting.
Trvalý link: http://hdl.handle.net/11104/0221594